Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer
Identifieur interne : 009528 ( Main/Exploration ); précédent : 009527; suivant : 009529Utility of intraoperative frozen section analysis of sentinel lymph nodes in breast cancer
Auteurs : Celia Chao [États-Unis] ; Sandra L. Wong [États-Unis] ; Douglas Ackermann [États-Unis] ; Diana Simpson [États-Unis] ; Mary B. Carter [États-Unis] ; C. Matthew Brown [États-Unis] ; Michael J. Edwards [États-Unis] ; Kelly M. Mcmasters [États-Unis]Source :
- The American Journal of Surgery [ 0002-9610 ] ; 2002.
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Abstract
Background: Intraoperative frozen section pathologic analysis of sentinel lymph node (SLN) may guide immediate (single-stage) completion axillary dissection for patients with nodal metastases.Methods: The results of 203 consecutive patients undergoing SLN biopsy who had intraoperative pathology consultation between January 1998 and September 2000 were reviewed. SLN were analyzed by standard frozen section procedures. Final pathologic analysis included hematoxylin and eosin (H&E) staining of serial sections at 2-mm intervals.Results: Frozen section analysis correctly identified a positive or negative result in 185 of 203 cases (overall accuracy 91%). In 17 of 53 cases, the SLNs were negative for tumor by frozen section, but positive on permanent section analysis (sensitivity 68%). The mean size of the nodal metastases was 6.2 mm and 1.5 mm in patients found to have true positive and false negative results, respectively (P <0.003). A single false positive SLN is reported.Conclusions: Two thirds of the patients were spared the need for reoperative axillary lymphadenectomy.
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DOI: 10.1016/S0002-9610(01)00794-2
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Matthew" last="Brown">C. Matthew Brown</name></author><author><name sortKey="Edwards, Michael J" sort="Edwards, Michael J" uniqKey="Edwards M" first="Michael J" last="Edwards">Michael J. Edwards</name></author><author><name sortKey="Mcmasters, Kelly M" sort="Mcmasters, Kelly M" uniqKey="Mcmasters K" first="Kelly M" last="Mcmasters">Kelly M. 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Graham Brown Cancer Center, University of Louisville School of Medicine, 2nd Floor ACB, Louisville, KY 40292</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Wong, Sandra L" sort="Wong, Sandra L" uniqKey="Wong S" first="Sandra L" last="Wong">Sandra L. Wong</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology, J. Graham Brown Cancer Center, University of Louisville School of Medicine, 2nd Floor ACB, Louisville, KY 40292</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Ackermann, Douglas" sort="Ackermann, Douglas" uniqKey="Ackermann D" first="Douglas" last="Ackermann">Douglas Ackermann</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Norton Hospital, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Simpson, Diana" sort="Simpson, Diana" uniqKey="Simpson D" first="Diana" last="Simpson">Diana Simpson</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology, J. Graham Brown Cancer Center, University of Louisville School of Medicine, 2nd Floor ACB, Louisville, KY 40292</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Carter, Mary B" sort="Carter, Mary B" uniqKey="Carter M" first="Mary B" last="Carter">Mary B. Carter</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology, J. Graham Brown Cancer Center, University of Louisville School of Medicine, 2nd Floor ACB, Louisville, KY 40292</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Brown, C Matthew" sort="Brown, C Matthew" uniqKey="Brown C" first="C. Matthew" last="Brown">C. Matthew Brown</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Norton Hospital, Louisville, KY</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Edwards, Michael J" sort="Edwards, Michael J" uniqKey="Edwards M" first="Michael J" last="Edwards">Michael J. Edwards</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology, J. Graham Brown Cancer Center, University of Louisville School of Medicine, 2nd Floor ACB, Louisville, KY 40292</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author><author><name sortKey="Mcmasters, Kelly M" sort="Mcmasters, Kelly M" uniqKey="Mcmasters K" first="Kelly M" last="Mcmasters">Kelly M. Mcmasters</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Surgery, Division of Surgical Oncology, J. Graham Brown Cancer Center, University of Louisville School of Medicine, 2nd Floor ACB, Louisville, KY 40292</wicri:regionArea><placeName><region type="state">Kentucky</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">The American Journal of Surgery</title><title level="j" type="abbrev">AJS</title><idno type="ISSN">0002-9610</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2002">2002</date><biblScope unit="volume">182</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="609">609</biblScope><biblScope unit="page" to="615">615</biblScope></imprint><idno type="ISSN">0002-9610</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-9610</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast cancer</term><term>Frozen section</term><term>Sentinel lymph node</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background: Intraoperative frozen section pathologic analysis of sentinel lymph node (SLN) may guide immediate (single-stage) completion axillary dissection for patients with nodal metastases.Methods: The results of 203 consecutive patients undergoing SLN biopsy who had intraoperative pathology consultation between January 1998 and September 2000 were reviewed. SLN were analyzed by standard frozen section procedures. Final pathologic analysis included hematoxylin and eosin (H&E) staining of serial sections at 2-mm intervals.Results: Frozen section analysis correctly identified a positive or negative result in 185 of 203 cases (overall accuracy 91%). In 17 of 53 cases, the SLNs were negative for tumor by frozen section, but positive on permanent section analysis (sensitivity 68%). The mean size of the nodal metastases was 6.2 mm and 1.5 mm in patients found to have true positive and false negative results, respectively (P <0.003). A single false positive SLN is reported.Conclusions: Two thirds of the patients were spared the need for reoperative axillary lymphadenectomy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Kentucky</li></region></list><tree><country name="États-Unis"><region name="Kentucky"><name sortKey="Chao, Celia" sort="Chao, Celia" uniqKey="Chao C" first="Celia" last="Chao">Celia Chao</name></region><name sortKey="Ackermann, Douglas" sort="Ackermann, Douglas" uniqKey="Ackermann D" first="Douglas" last="Ackermann">Douglas Ackermann</name><name sortKey="Brown, C Matthew" sort="Brown, C Matthew" uniqKey="Brown C" first="C. Matthew" last="Brown">C. Matthew Brown</name><name sortKey="Carter, Mary B" sort="Carter, Mary B" uniqKey="Carter M" first="Mary B" last="Carter">Mary B. Carter</name><name sortKey="Edwards, Michael J" sort="Edwards, Michael J" uniqKey="Edwards M" first="Michael J" last="Edwards">Michael J. Edwards</name><name sortKey="Mcmasters, Kelly M" sort="Mcmasters, Kelly M" uniqKey="Mcmasters K" first="Kelly M" last="Mcmasters">Kelly M. Mcmasters</name><name sortKey="Simpson, Diana" sort="Simpson, Diana" uniqKey="Simpson D" first="Diana" last="Simpson">Diana Simpson</name><name sortKey="Wong, Sandra L" sort="Wong, Sandra L" uniqKey="Wong S" first="Sandra L" last="Wong">Sandra L. Wong</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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